Dendritic cell maturation by innate lymphocytes
نویسندگان
چکیده
Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes--natural killer (NK), natural killer T (NKT), and gammadelta T cells--also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 202 شماره
صفحات -
تاریخ انتشار 2005